Abstract: Employing ABC immunoperoxidase and double immunofluorescence technique, we observed the distribution of Langerhans cells (LCs) and the presence of IgE⁺/OKT₆⁺LCs in the lesional cryosettions of atopic dermatitis (AD) and other dersnatases. We also tested the serum IgE levels on some of those patients using ELISA method. The results showed that: The presence of IgE⁺/OKT₆⁺LCs was not only found in the lesions of AD and cutaneous T cell lymphoma with elevated semen IgE levels, but also found in the lesions of eczema, alergic contact dermatitis and other non-AD Cermtoses with normal serum IgE levels. The presence of IgE-LCs was not specific for AD.

Key words: Dermatitis atopic, IgE, Lan gerhans cells