Abstract: The effects of five chemical compounds on germ tube formation, chlamydospore formation and nucleic acid metabolism of Candida albicans were observed. The result showed that MgCl₂ and CsCl₂ could promote germ tube formation. Na₂SeO₃,CdI₂ and CuCl₂ inhibited germ tube formation as ketooonazole did. MgCl₂ promoted chalmydospore formation, but CsCl₂, CuCl₂, Na₂SeO₃ and,CdI₂ inhibited it. By the method of incorporation with ³H-TdR, we observed the effects of five chemical compounds on nucleic acid metabolism of Cantdida albicanc. The results showed that MgCl₂ and CsCl₂ promoted nucleic acid metabolism, CuCl₂, Na₂SeO₃ and CdI₂ inhibited the metabolism, the higher the concentration,the stronger the inhibition was, showing the same effect as ketoconazole.

Key words: Candida albicans, Germ tube Ghlamydospore, Nucleic acid metabolism