Abstract: Objective To investigate the distribution of E-selectin polymorphisms in Guangxi ethnic Zhuang population and the association of E-selectin gene polymorphism in exon 2 and in exon 4 with systemic lupus erythematosus(SLE). Methods Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to study the E-selectin polymorphisms in 82 patients with SLE and 95 healthy controls of ethnic Zhuang population in Guangxi Province. Results The frequencies of GG、GT、TT genotypes in the exon 2 of E-selectin were 86.6%,12.2%, and 1.2% in SLE group; 90.5%, 8.4%, and 1.1% in the control group, respectively. The frequencies of AA、AC、CC genotypes in the exon 4 and E-selectin were 81.7%,15.9%, and 2.4% in SLE group; 92.6%,7.4%, and 0.0% in the control group, respectively. There was a significant difference in the frequencies of allele and genotype in E-selectin A561C polymorphism between SLE group and control group(P<0.05). The relative risk suffered from SLE in those with AC+CC genotype was 2.814 times of the AA genotype(OR=2.814,95%CI:1.087～7.290). Conclusions E-selectin A561C polymorphism is associated with SLE and C allele may be a risk factor for SLE in ethnic Zhuang population in Guangxi.

Key words: Lupus erythematosus, systemic, E-selectin, Polymorphism, restriction fragment length