Abstract: TANG Zhi-ming, JING Meng-qing, ZHAI Xiao-xiang, ZHANG Cui-xia, LI Jing-guo. Department of Dermatology, Xuzhou Hospital of Traditional Chinese Medicine, Xuzhou 221003, Jiangsu, China Corresponding author: TANG Zhi-ming, Email: 158914788@qq.com 【Abstract】 Objective To evaluate the efficacy of Xuebijing injection plus oral acitretin for the treatment of erythrodermic psoriasis. Methods　Forty-eight patients with erythrodermic psoriasis were equally and randomly divided into two groups by a random number table: test group treated with Xuebijing injection once a day plus oral acitretin, and control group treated with oral acitretin. The dose of acitretin began at 0.5 mg per kilogram per day, and was modified according to the tolerance in and response of patients. After 8 weeks of treatment, clinical efficacy was evaluated by psoriasis area and severity index （PASI） score, response rate and recurrence rate. Adverse reactions were also recorded and evaluated. Results The difference in PASI score between pre- and post-treatment was significantly higher in the test group than in the control group （ 34.9 ± 2.2 vs. 27.3 ± 1.7, t = 3.37, P < 0.05）. The total response rate was 87.5% in the test group and 62.5% in the control group （χ2 = 4.87, P < 0.05）. There was a statistical decrease in the average onset time （（13.5 ± 2.4） d vs.（20.7 ± 3.1） d, t = 3.67, P < 0.05）, daily dose and total dose of acitretin （（26.4 ± 3.3） mg vs. （34.7 ± 3.5） mg, （1854.5 ± 85.2） mg vs. （2768.8 ± 88.7） mg, t = 3.07, 4.32, respectively, both P < 0.05） in the test group compared with the control group. The recurrence rate was 9.5% （2/21） in the test group and 26.6% （4/15） in the control group （χ2 = 5.23, P < 0.05）. Conclusion In the case of erythroderma psoriaticum, Xuebijing injection combined with oral acitretin is superior to oral acitretin alone in clinical efficacy, onset time and reducing recurrence.