Abstract: Experimental lesions were produced in mice by inoculating Sporothrix schenckii suspension intracuta neously.The morphologic features of the organisms in tissue sections were observed with various methods and studied concerning their significance in histopathological diagnosis.The results defined that with H.E staining,the spores were found to be charac teristically surrounded by a narrow clear halo.The lectin binding pattern of the organisms in tissue sec tions was similar to that in culture,which was different from several other kinds of deep fungi.It was found that the semi-thin section embedded in Epon had an outstanding advantage both in detecting the organisms and showing the relation between the organisms and the host cell.The results showed that the morphologic changes of the organisms in tissue related to the host resistance.

Key words: Sporotrichum, Mice, Pathology