Abstract: In order to investigate the effects of cis-UCA on cell-mediated immunity, we established a murine model of DTH response to DNP₆OVA which is indicated by the increasing in the ear thickness of the mouse after resensitization, compared with those of the mouse injected with 200 g cis-UCA and trans-UCA intraperitoneally (i.p.). The average of the increasing in ear thickness of each group was 9.1±1.13×10^-2 mm (n=8, the number of ears) for the group administrated with cis-UCA; 17.45±0.88×10^-2 mm (n=8) for the group administrated with trans-UCA; 16.43+1.83×10^-2 mm(n=7) for control group. It is suggested that there are immunosuppression of DTH response to DNP₆OVA in mouse administrated with ets-UCA and no effecs of trans-UCA on this response.

Key words: Urecanic acid Ultraviolet rays Hypersensitivity, delayed type