Chinese Journal of Dermatology ›› 1995, Vol. 28 ›› Issue (4): 219-221.

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Study on Karyomorphometry and Proliferating Rate of Cutaneous Malignant Lymphomas

Qiu Bingsen1, Gao Ge2   

  1. Institute of Dermatology, Shanghai Medical University, Shanghai 200040
  • Received:1994-09-29 Revised:1994-12-19 Online:1995-08-15 Published:1995-08-15

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Abstract: The same paraffin-embedded specimen of skin biopsy from each of 29 patients with cutaneous malignant lymphomas (CML) and 7 patients with cutaneous lymphoid infiltrates (CLI) was estimated simultaneously and retrospectively by karyomorphometry and proliferating rate assay. The results showed that the differences in nuclear volumes (NVs), count of argyrophilic nucleolar organizer regions(AgNORs) and proliferating cell nuclear antigen (PCNA-PC10) indices (PC10Is) between CML and CLI were statistically very significant. The NVs and PC10Is were correlated to the death rate of patients. NVs were also correlated to AgNORs.

Key words: Lymphoma, Karyomorphometry, Cell proliferating rate