Abstract: To evaluate the relationship between the family atopic history(FAH) and clinical,laboratory parameters and diagnosis in patients with atopic dermatitis(AD).One hundred and fifty-eight AD patients were included in this study and the patients were divided into two groups,89 eases (56.3%) with FAH and 69 cases(43.7%) without FAH.The personal and family atopie history,the distribution and morphology of the lesions,five associated clinical manifestations and laboratory tests were performed in 158 cases with AD.In comparison of the patients with FAH with the cases without FAH,the age of onset in AD patients under two years was 92.1% and 84.1%,respectively;persistent course, 55.1% and 43.5%;the average time of intermittent course,5.7 years and 9.6 years;the age of onset of respiratory tract allergy(AR),4.1 years and 6.2 years in cases with asthma,8.8 years and 11.1 years in allergic rhinitis (R).The morbidity of asthma in patients with personal and family atopic history was higher and it was higher in Ⅰ and Ⅱ generation also.The levels of serum IgE in AD patients with personal and family history of AR were higher than those in without AR history(P<0.01).In AD patients with FAH,the age of onset was younger,persistent course was longer,intermittent course was shorter. The morbidity of asthma was higher in the patients with personal and family atopic history and the atopic history of close generation was more important than those of distant generation.In AD patients with personal and family history of AR,the levels of serum IgE were significantly higher and elevated levels of serum IgE correlated with the severity of dermatitis.

Key words: Dermatitis,atopic, Family, Hypersensitivity