Abstract: In order to study the mechanism of Futaibao (a Chinese traditional herbpreparation composed of Radix Salviae miltiorrhizae,Radix arnebiae euchroma,Radix notoginseng and Tripterygium wilfordi etc.)in the treatment of psoriasis,vascular endothelial cell lines F-2 and F-2C derived from mouse skin were used to observe the efects of Futaibao on the biological activity of endothelial cell lines.The results showed that:①Futaibao inhibited the migration and proliferation of the endothelial cells,and canalization was induced,②promoted the endothelial cells to synthesize extracelular matrix(collagenⅣ,fibronectin,and laminin),③regulated the expression of integrin,④markedly increased the activity of cadherin.The results suggest that Futaibao controls angiogenesis process through a series of mechanisms.

Key words: Vascular endothelial cell, Herbs,Chinese traditional