Abstract: Generalized pustular psoriasis(GPP) in children is rare.Twenty-three inpatients with GPP in children(16 males and 7 females,age ranged from 2 to 12 years,with an average of 7.35 years)were analyzed.Clinical observation revealed that upper respiratory tract infection and irregular corticosteroid therapy were important factors in inducing and aggravating the disease.Twenty patients were treated with a combination of Leigongteng(Tripterygium wilfordi),dapsone and erythromycin,7 of them(35%)cured,9(45%)improved in 1～2 weeks.It is th eauthor's opinion that the above regimen is the first choice of treatment for GPP,and tigason、methotrexate are the alternatives,while corticosteroids are not recommended as the routine therapeutic drugs.The children's age,underlying disease and the rapeutic regimen have efect on prognosis of the disease.

Key words: Pustular psoriasis, Therapeutics