Abstract: The effectsoftopicalapplication of 1% ofloxacin cream, 1% ofloxacin com pound cream (containing 0.3% spironolactone), 0.3% spironolactone in isopropyl alcohol and 5% Tanshinone cream on the flank organsofadultm ale Syrian ham sters were investigated. Allthe agents were applied on the right flank organs twice per day, while the left were untreated. The results showed that 1% ofloxacin cream had no effecton the flank organs. The effect of 1% ofloxacin compound cream on the flank organs was equalto that of 0.3% spironolactone cream, this indicated that the ofloxacin in 1% of loxacin compound cream had no influence on the action of spironolactone. The effect of 0.3% spironolactone in isopropyl alcoholw as stronger than that of 0.3% spironolactone cream. The seba-ceous gland-suppressive action ofTanshinone was markedly stronger than thatofspironolactone.

Key words: Flank Organ, Syrian Ham ster, Ofloxacin, Spironolactone, Tanshinone