Chinese Journal of Dermatology ›› 1998, Vol. 31 ›› Issue (1): 14-15.

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Preliminary Study of Expression of CD43 Antigen on Lymphocytes of Peripheral Blood in Patients with SLE

Liang Zaifu1, Zang Shifa2, Xu Jing1   

  1. Department of Dermatology, No.1 Hospital of China Medical University, Shenyang 110001
  • Received:1997-07-15 Revised:1997-10-05 Online:1998-02-15 Published:1998-02-15

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Abstract: Objective To investigate the causes of immunological disorders in SLE.Methods CD43 antigen on lymphocytes of peripheral blood in 16 cases of active SLE was detected by immunoflourescent double marker-flow cytometry.Results The results showed that,(1) the number of CD43 antigen positive lymphocytes in peripheral blood of active SLE patients was 63.14±16.47,which was significantly lower than that of the control group(86.6 2±12.86,P<0.01).(2) The number of CD43 antigen positive cells was negatively correlated to the disease activity of SLE (r=-0.702,P<0.01). (3) The number of CD19+-CD43+ lymphocytes in peripheral blood in active SLE was 2.5 5±1.38w hich was significantly higher than that of the control group (1.32±0.92,P<0.01).Conclusion The increase of CD19+-CD43+ lymphocytes may be correlated with the production of anti-DNA autoantibody in SLE.

Key words: Lupus erythematosus, systemic Flowcytometry, CD43