Abstract: Objective To study the role of tumor necrosis factor alpha(TNF-), interleukin(IL) 6 and IL-8 in the pathogenesis of condyloma acuminatum(CA). Methods Double-antibody sandwich ELISA was used to study the levels of TNF-,IL-6 and IL-8 in 21 cases of CA. Results The results showed that the levels of TNF-,IL-6 and IL-8 of the plasma in the patients were significantly lower than those of normal controls. The levels of TNF-,IL-6 and IL-8 produced by peripheral blood mononuclear cells in response to LPS mitogen in vitro significantly decreased in comparison with those of normal controls. The levels of IL-6 and IL-8 of the wart tissues excised from 17 patients were significantly lower than those of normal tissue. No TNF- was detected in the tissues of both patient and normal groups. Conclusion These findings suggest that the monocyte macrophage function of CA patients might be decreased systemically and locally which may contribute to the disorder of lymphocyte function. Improvement of the monocyte macrocyte function might have some significant effect on the prevention and treatment of CA.

Key words: Condyloma acuminatum, Tumor necrosis factor-, Interleukin 6, Interleukin 8