Abstract: Objective To study the percentage and the distribution of nosocomial infection,and susceptibility of related pathogens to antibiotics in patients with systemic lupus erythematosus (SLE). Methods The clinical data of in patients with SLE in our hospital from June,1990 to June,1998 were analyzed. The susceptibility of the pathogens to antimicrobial agents was tested by K-B paper dilution method. Results The percentage of nosocomial infection in these cases was 16.1%. The major pathogens were staphylococcas aureus,Escherichia coli and Candida. The most highly resistant microbes were E.coli,S.arueus and Pseudomonas aeruginosa. Conclusions The nosocomial infection is one of the most common complication of SLE in the in patients. It is necessary to examine the pathogens regularly and use antibacterial agents according to the susceptibility.

Key words: Lupus erythematosus,systemic, Cross infection, Drug resistance