Abstract: Objective To investigate the association of two microsatellite markers, D17S784 and D17S928, with psoriasis vulgaris. Methods Fluorescent multiplex PCR, genescaning and Genotype^TM software were employed to amplify the microsat ellite DNA markers and conduct genotyping. Results The significant association w as found between D17S784, D17S928 and psoriasis vulgaris (P<0.001). The frequencies of their gene fragments were significantly different between patients and healthy controls. Conclusion D17S784 and D17S928 may be the very attractive candidate gene regions for further studies in psoriasis patients.

Key words: Psoriasis, Chromosomes,human,pair 17