Abstract: Objective To isolate and identify pathogenic fungus in a patient with intracranial infection.Methods Specimens were taken from the spinal fluid of the patient.Then,microscopy and fungal culture were done to identify the pathogen.The histopathologic features were reprod uced through animal pathogenicity study in a nice model.Results According to the colony appearance in culture medium,the morphological features in microscopy,such as conidia arrangement and size,germtube forming site,this fungus was identified as Bipolaris spicifera.Hyphae and swollen hyphal cells resembling chlamydospores,septate pigmented hyphae were observed in braintissue specimen of mice experimental model,which were consistent with phaeohyphomycosis.Conclusion This is the first case of phaeohyphomycosis caused by Bipolaris spicifera reported in China.

Key words: Bipolaris spicifera, Phaeohyphomycosis