Abstract: Objective To study the clinical significance of systemic lupus erythematosus disease activity index(SLEDAI) in the treatement of SLE. Methods Disease activity of every patient with SLE 10 days before admission and before discharging was assessed using the SLEDAI system. The patients were treated separately with prednisone, pulse methylprednisolone and/or pulse cyclophosphamide according to their conditions. Statistical analysis was carried out using SPSS software. Results ①The difference of SLEDAI between the patients before admission and discharging was significant (P<0.001). ②The difference of SLEDAI among different treatment groups was significant. ③There was a positive correlation between the dosage of prednisone, methylprednisone, cyclophosphamide and SLEDAI. ④Different treatment choice was associated with different organ/system involvement. Conclusion SLEDAI is an effective indicator in evaluating disease activity of SLE patients, which is useful in SLE treatment.

Key words: Lupus erythematosus, systemic, Prednisone, Immunosuppressive agents