Chinese Journal of Dermatology ›› 2002, Vol. 35 ›› Issue (4): 256-259.

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Treatment of Murine Allergic Contact Dermatitis with CTLA4-Ig

ZHOU Qian1, KOU Geng1, QIAN Weizhu1, WANG Hao1, LIU Yanjun1, WANG Xiaoyun1, SONG Shuichuan1, JIN Jun1, LI Xiaodong1, WU Mengchao2, GUO Yajun1, CHEN Lieping3   

  1. International Joint Cancer Institute, Second Military Medical University, Shanghai 200433, China
  • Received:2001-09-07 Online:2002-08-15 Published:2002-08-15

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Abstract: Objective To study the effects of CTLA4-Ig on murine allergic contact dermatitis.Methods Mice were exposed to DNFB to induce allergic contact dermatitis and were injected with CTLA4-Ig.Ear swelling was measured 24h after antigen challenge.Splenocytes from treated mice were assayed for their ability to prolif erate in response to DNFB or FITC stimulation in vitro.Results Profound inhibition of contact hypersensitivity response(CHS) was shown by 69.7% in mice treated with CTLA4-Ig compared with mice treated with PBS control.CT-LA4-Ig-treated mice displayed DNFB-specific tolerance,but exhibited a vigorous immune response to FITC when re-sensitizing 14 days after the first challenge.Adoptive transfer of l ymphocytes from CTLA4-Ig-treated mice could induce inhibition of CHS in recipient mice.Conclusions CTLA4-Ig can inhibit CHS by blocking B7/CD28 co-stimulatory pathway,which provides a new way to suppress typeⅣ allergic reaction.

Key words: Dermatitis,allergic contact, CTLA4-Ig