银屑病患者血小板活化因子乙酰水解酶基因突变的研究

Abstract

Abstract: Objective To investigate the relationship between a mutation in the platelet-activating factor (PAF) acetylhydrolase gene (Arg92→His) and psoriasis. Methods Genomic DNA was analyzed in 47 patients with psoriasis and 52 healthy controls via polymerase chain reaction and restriction fragment length polymorphism. Results The frequency of the mutation in the PAF acetylhydrolase gene (Arg92→His) was significantly higher in patients with psoriasis than that in the controls (P<0.05). Conclusion The mutation (Arg92→His) in PAF acetylhydrolase gene, which is related to psoriasis, may be a genetic risk factor for psoriasis.

Key words: Psoriasis, 1-Alkyl-2-acetylglycerophosphocholine esterase, Mutation

XIA Tian-bao, BI Xin-ling, GU Jun, MIAO Ming-yong, LI Su-ling, WANG Jie, SUN Qing-ju, YU Jun. Platelet-activating Factor Acetylhydrolase Gene Mutation and Psoriasis[J].Chinese Journal of Dermatology, 2005, 38(11): 677-679.

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Platelet-activating Factor Acetylhydrolase Gene Mutation and Psoriasis

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