淋巴瘤样丘疹病继发蕈样肉芽肿:共同T细胞克隆增生一例报告

Abstract

Abstract: Objective To report a case of lymphomatoid papulosis(LyP)followed by mycosis fun-goides(MF)during his 27 years course and determine whether these diseases are clonally related.Methods Characteristics of clinicopathology and immunophenotype of skin tissues of different phases of the patients were compared.Simultaneously,clonal T-cell receptor gene rearrangement of skin lesion tissues and blood specimens were detected by means of polymerase chain reaction and Southern blot analysis.Results A distinctc clinisal and pathological feature was shown in this case df LyP flowed by MF.The proliferating lymphocytes in LyP and MF were mature T helper lymphocytes,and with same T-cell clone.Conclusion LyP folloewd by MF displays a same T-cell clone.The clonal T-cell is irrelevant to the biological behavior of these diseases.

Key words: Lymphomatoid papulosis, Lymphoma,T-cell, T-lymphocytes, Immunophenotyping

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WANG Ping, QIU Bing-sen, GAO Hong-yang, CHEN Ming-hua, SHAN Yi-fei. A Case Report of Lymphomatoid Papulosis Followed By Mycosis Fungoides:Derived from a Common T Cell Clone[J].Chinese Journal of Dermatology, 2003, 36(6): 303-305.

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References

[1] Karp DL, Horn TD. Lymphomatoid papulosis. J Am Acad Dermatol,1994, 30: 379-395.
[2] Davis TH, Morton CC, Miller-Cassnan R, et al. Hodgkin's disease,lymphomatoid papulosis, and cutaneous T-cell lymphoma derived from a common T-cell clone. N Engl J Med, 1992, 326:1115-1122.
[3] LeBoit PE. Lymphomatoid papulosis and cutaneous CD30⁺ lymphoma. Am J Dermatopathol, 1996, 18:221-235.
[4] Beljaards RC, Willemze R. The prognosis of patients with lymphomatoid papulosis associated with malignant lymphomas. Br J Dermatol, 1992, 126:596-602.
[5] Basarab T, Fraser-Andrews EA, Orchard G, et al. Lymphomatoid papulosis in association with mycosis fungoides: a study of 15 cases. Br J Dermatol, 1998, 139:630-638.
[6] Chott A, Vonderheid EC, Olbricht S, et al. The dominant T cell clone is present in multiple regressing skin lesions and associated T cell lymphomas of patients with lymphomatoid papulosis. J Invest Dermatol, 1996, 106:696-700.
[7] Whittaker S, Smith N, Jones RR, et al. Analysis of beta, gamma,and delta T-cell receptor genes in lymphomatoid papulosis: cellular basis of two distinct histologic subsets. J Invest Dermatol, 1991,96: 786-791.
[8] Dadej K, Gaboury L, Lamarre L, et al. The value of clonality in the diagnosis and follow-up of patients with cutaneous T-cell infiltrates.Diagn Mol Pathol, 2001, 10:78-88

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A Case Report of Lymphomatoid Papulosis Followed By Mycosis Fungoides:Derived from a Common T Cell Clone

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[1]	Zhang Yangyang, Li Bing, Wang Gang. Phenotype identification of CD8αα+ T cells infiltrating psoriatic skin lesions [J]. Chinese Journal of Dermatology, 2018, 51(10): 729-732.
[2]	. Detection of T cells and melanocytes in skin of patients with psoriasis and their clinical significance [J]. Chinese Journal of Dermatology, 2015, 48(4): 240-244.
[3]	. Detection of peripheral CD4+CD25+ regulatory T （Treg） cells in patients with atopic dermatitis [J]. Chinese Journal of Dermatology, 2010, 43(9): 610-613.
[4]	GUO Yi-Long . Detection of peripheral dendritic cell subsets and T cell subpopulations expressing different intracellular cytokines in patients with syphilis [J]. Chinese Journal of Dermatology, 2008, 41(9): 612-.
[5]	Chang Jing . Study on psoriatic peripheral blood T-lymphocytes: effects of CD147-targeting small interfering RNA on the expression of CD147 and on cell proliferation and activation [J]. Chinese Journal of Dermatology, 2008, 41(12): 783-.
[6]	. Expression of CD70 in T lymphocytes from patients with systemic lupus erythematosus [J]. Chinese Journal of Dermatology, 2008, 41(11): 739-.
[7]	TAN Guo-zhen, PENG Hui, MAO Yue-ping, ZENG Fan-qin. Glucocorticoids treatment upregulates the expression of CD62L in CD4⁺CD25⁺T cells in peripheral blood monocytes of patients with systemic lupus erythematosus [J]. Chinese Journal of Dermatology, 2007, 40(6): 362-364.
[8]	LIU Dong-xian, JIANG Wen, CHEN Xing-ping, CHEN Ying-ling, YANG Dong-liang. Expression of cytokines in CD8⁺ T lymphocytes of the peripheral blood of patients with condyloma acuminatum [J]. Chinese Journal of Dermatology, 2007, 40(11): 674-675.
[9]	RUAN Li-ming, WU Wei, WANG Yi-na, LIU Xiao-yan, JIANG Xiao-ling, CHEN Hong-chao. Expression of B7-CD28/CTLA-4 in peripheral blood lymphocytes of female patients with genital condyloma acuminatum [J]. Chinese Journal of Dermatology, 2007, 40(11): 691-693.
[10]	FENG Su-ying, JIN Pei-ying, ZENG Xue-si, JIANG Yi-qun. A case of hydroa vacciniforme-like primary cutaneous CD8-positive T-cell lymphoma [J]. Chinese Journal of Dermatology, 2007, 40(10): 598-600.
[11]	CHEN Xiang, LI Juan, SU Juan, WU Yi-xi, CHANG Jing, PENG Sheng, KUANG Ye-hong. Expression of CD147,cyclophilin A and cyclophilin B in psoriatic lesions [J]. Chinese Journal of Dermatology, 2007, 40(10): 622-624.
[12]	QIAN Qi-feng, ZHANG Ming-xia. Quantification of peripheral blood HPV16 antigen-specific CD8⁺ cytotoxic T cells in patients with condyloma acuminatum [J]. Chinese Journal of Dermatology, 2006, 39(5): 260-262.
[13]	ZHAO Jian-bin, GONG Kuang-long, ZHANG Jin-ping, ZHONG Ming-ying, SHANG Shu-xian, ZHENG Bo, WANG Oian-qiu. CD4⁺CD25^brightregulatory T cells in peripheral blood of patients with syphilis [J]. Chinese Journal of Dermatology, 2006, 39(5): 247-249.
[14]	FENG Ai-ping, ZHAO Jing, WU Yan, QIAN Yue, CHEN Si-yuan, LIAN Xin, TU Ya-ting. Proliferating T cells and dendritic cells in the skin lesions of patients with mycosis fungoides [J]. Chinese Journal of Dermatology, 2006, 39(4): 207-209.
[15]	SONG Xiu-zu, XU Ai-e, ZHOU He-fen. The expression of MCP-1 and sICAM-1 in skin tissue fluid and regulatory T cells in blood of vitiligo patients in stable stage [J]. Chinese Journal of Dermatology, 2006, 39(2): 95-97.