Chinese Journal of Dermatology ›› 2003, Vol. 36 ›› Issue (12): 675-678.

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Identification of Hereditary Symmetrical Dyschromatosis Susceptibility Locus by Genome-wide Scan

GAO Min1, ZHANG Xue-jun1, LI Ming1, LI Cheng-rang1, CUI Yong1, HE Ping-ping1, LI Ming2, YUAN Wen-tao2, XU Shi-jie2, YANG Sen1, HUANG Wei2   

  1. Institute of Dermatology, Anhui Medical University, Heifei 230022, China
  • Received:2003-01-09 Online:2003-12-15 Published:2003-12-15

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Abstract: Objective To identify a locus for hereditary symmetrical dyschromatosis(HSD).Methods A genome-wide scan was performed with 402 microsatellite markers in two large Chinese HSD families to map the chromosome location of the susceptible gene.The LINKAGE software(Version5.10)and CYRILLIC soft-ware(Version 2.01)were used for linkage and haplotype analysis.Results A locus was identified at chro-mosome 1q11-1q21 with a cumulative maximum two-point LOD score of 8.85 at microsatellite marker D1S2343(θ=0.00).Haplotype analysis indicated that the candidate gene was located within 11.6 cM region between markers D1S2696 and D1S2635.This was the first locus identified for HSD.This study provided a map location for isolation of the candidate genes causing HSD.Conclusion Chromosome1q11-1q21contains the candidate gene susceptible for dyschromatosis symmetrica hereditaria.

Key words: Chromosome mapping, Linkage(Genetics), Haplotypes, Dyschromatosis symmetrica hereditaria