Abstract: Objective To assess the clinical efficacy and safety of Solcoderm in the treatment of verruca vulgaris, and to compare with that of cryosurgery. Methods A randomized open, parallel controlled, multi-center clinical trial was conducted. Results The clearance rate in target warts(primary efficacy) was 71.6% in Solcoderm group, and 77.5% in cryosurgery group(P=0.451); the clearance rate(secondary efficacy)in other warts was 58.7% versus 75.3% respectively(P=0.034). Adverse reaction rate was 4.1% in Solcoderm group and 1.4% in cryosurgery group(P>0.05). Conclusions Solcoderm is a simple, safe, and efficient method for the treatment of verruca vulgaris.

Key words: Cryotherapy, Warts, Randomized controlled trials