Chinese Journal of Dermatology ›› 2004, Vol. 37 ›› Issue (11): 651-652.

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The Expression of Cyclooxygenase-2 in Several Epidermal Tumors

RUAN Li-ming1, LIU Guo-ying1, LIU Xiao-yan1, WANG Li-jun2, YAN Li-ping2, LU Lian-zhi1   

  1. Department of Dermatology, First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310003, China
  • Received:2003-11-05 Online:2004-11-15 Published:2004-11-15

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Abstract:

Objective To explore the expression of cyclooxygenase-2 (COX-2) in different epidermal tumors and its significance.Method The expression of COX-2 was detected by immunohistochemical staining of skin specimens from 10 cases of basal cell carcinoma (BCC),8 squamous cell carcinoma (SCC),8 Bowen's disease (BD),12 seborrheic keratosis (SK) and 10 normal volunteers.Results Compared with normal epidermal cells,COX-2 expression was significantly increased in BCC,SCC and BD cells.Especially,COX-2 expression in SCC was the most intensive.COX-2 expression in SK cells was similar to that of normal epidermal cells.Conclusion The up-regulation of COX-2 expression may play a potential role in the pathogenesis of epidermal tumors.

Key words: Prostaglandin-endoperoxide synthase, Carcinoma,basal cell, Carcinoma,squamous cell, Bowen’s disease, Keratosis,seborrheic