Abstract:

Objective To determine the genotypes of human papillomavirus （HPV） in patients with giant condyloma acuminatum. Methods Sixty-seven outpatients with giant condyloma acuminatum collected from January 2007 to January 2010 were included in this study. Lesional specimens were obtained from these patients. The genotypes of HPV were determined by flow-through hybridization and gene chip assay. Results Of the 67 cases of giant condyloma acuminatum, 63 （94.02%） were positive for HPV DNA. Among the HPV DNA-positive specimens, 84 （60.87%） harbored low risk types of HPV, 54 （39.13%） high risk types of HPV. Type 6 and 11were the predominant low risk HPV types, while type 16 and 18 were the major high risk HPV types. Conclusion There is an elevated prevalence of high risk HPV types 16 and 18 in patients with giant condyloma acuminatum.

Key words: HPV subtypes