Abstract:

Objective To evaluate the clinical efficacy of three different placental preparations in the treatment of childhood vitiligo. Methods Eighty-two children with vitiligo were divided into 3 groups to be topically treated with melagenine, human placental tissue fluid and human placental lipopolysaccharide respectively. All the patients were additionally treated with infrared rays for 20 minutes twice daily. The drugs were topically applied with an interval of 5 minutes during the irradiation. Results The response rate was 75.65%, 35.00% and 44.44% respectively in the melagenine-, human placental tissue fluid- and human placental lipopolysaccharide-treated patients, and significant differences were observed between the three groups of patients （all P < 0.05）. In particular, melagenine was superior to the other two preparations for the treatment of large areas of vitiligo on the scalp. Conclusion The 3 placental preparations combined with infrared irradiation show favorable efficacy for the treatment of childhood vitiligo.