Abstract:

Abstract Objective To observe the therapeutic effect and safety of Epinastine to treat dermatographism.Methods An open multicenter investigation was conducted to compare Epinastine with Loratadine.Resultes The cure rate of experiment group was 54.1%,and total effective rate was 82.4%.The cure rate of control group was 45.8%, and total effective rate was 71.6%. There was significant difference between the two groups of total effective rate(P<0.05) ,and no significant difference of adverse effect.Conclusion The curative effect of Epinastine was better than Loratadine,and there was no significant difference of safety between the two grops.

Key words: dermatographism