参考文献 1. Eustace AJ,Mahgoub T,Tryfonopoulos D,O'Donovan N,Crown J. Prospects for non-immunological molecular therapeutics in melanoma.J BUON.2010;15(1):9-18. 2. Shepherd C, Puzanov I, Sosman JA. B-RAF inhibitors:an evolving role in the therapy of malignant melanoma.Curr Oncol Rep.2010; 12(3):146-52. 3. Bedikian AY, Richards J, Kharkevitch D, Atkins MB, Whitman E, Gonzalez R. A phase 2 study of high-dose allovectin-7 in patients with advanced metastatic melanoma.Melanoma Res.2010;29.[Epub ahead of print] 4. Monaghan DT, Bridges RJ, Cotman CW: The excitatory amino acid receptors: their classes,pharmacology, and distinct properties in the function of the central nervous system. Annu Rev Pharmacol Toxicol 1989;29: 365–402 5. Dingledine R, Borges K, Bowie D, Traynelis SF: The glutamate receptor ion channels. Pharmacol Rev 1999; 51:7–61. 6. Pollock PM, Cohen-Solal K, Sood R, et al.Melanoma mouse model implicates metabotropic glutamate signaling in melanocytic neoplasia.Nat Genet.2003;34(1):108-12. 7. Stepulak A, Sifringer M, Rzeski W,et al.NMDA antagonist inhibits the extracellular signal-regulated kinase pathway and suppresses cancer growth.Proc Natl Acad Sci U S A.2005 25;102 (43):15605-10. 8. Rzeski W, Turski L, Ikonomidou C.Glutamate antagonists limit tumor growth.Proc Natl Acad Sci U S A.2001 22;98(11):6372-7. 9. 卢平,周育森, 陈万荣,单路娟,李军峰,宋智琦.谷氨酸受体通路对恶黑细胞树突形态及其细胞骨架蛋白的作用研究.中华皮肤科杂志,2009,42(8),41-44. 10. Shin SS,Namkoong J,Wall BA,Gleason R,Lee HJ,Chen S.Oncogenic activities of metabotropic glutamate receptor 1 (Grm1) in melanocyte transformation.Pigment Cell Melanoma Res.2008;21 (3):368-78. 11. Namkoonk J, Shin SS, Lee HJ, Marin YE, Wall BA, Goydos JS, Chen S.Metabotropic glutamate receptor 1 and glutamate signaling in human melanoma.Cancer Res 2007;67:2298–305. 12. Shin SS,Wall BA,Goydos JS,Chen S.AKT2 is a downstream target of metabotropic glutamate receptor 1 (Grm1).Pigment Cell Melanoma Res.2010; 23(1):103-11. 13. Arcella A, Carpinelli G, Battaglia G,et al.Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo.Neuro Oncol.2005;7(3):236-45. 14. D'Onofrio M,Arcella A,Bruno V,et al.Pharmacological blockade of mGlu2/3 metabotropic glutamate receptors reduces cell proliferation in cultured human glioma cells.J Neurochem.2003;84(6):1288-95. 15. Brocke KS,Staufner C,Luksch H, Geiger KD,et al.Glutamate receptors in pediatric tumors of the central nervous system. Cancer Biol Ther.2010;9(6).[Epub ahead of print] 16. Chang HJ,Yoo BC,Lim SB,Jeong SY,Kim WH,Park JG.Metabotropic glutamate receptor 4 expression in colorectal carcinoma and its prognostic significance.Clin Cancer Res. 2005;11(9):3288-95. 17. Yoo BC,Jeon E,Hong SH,Shin YK,Chang HJ,Park JG.Metabotropic glutamate receptor 4-mediated 5-Fluorouracil resistance in a human colon cancer cell line. Clin Cancer Res.2004;10(12 Pt 1):4176-84. 18. Stepulak A,Sifringer M,Rzeski W,et al.AMPA antagonists inhibit the extracellular signal regulated kinase pathway and suppress lung cancer growth.Cancer Biol Ther.2007;6(12): 1908 -15. 19. Marín YE, Namkoong J, Shin SS, Raines J, Degenhardt K, White E, Chen S. Grm5 expression is not required for the oncogenic role of Grm1 in melanocytes.Neuropharmacology.2005;49 Suppl 1:70-9. 20. Namkoong J, Shin SS, Lee HJ, Marín YE, Wall BA, Goydos JS, Chen S: Metabotropic glutamate receptor 1 and glutamate signaling in human melanoma.Cancer Res. 2007;67(5):2298-305. 21. Ives JH,Fung S,Tiwari P,Payne HL, Thompson CL.Microtubule- associated protein light chain 2 is a stargazin-AMPA receptor complex-interacting protein in vivo.J Biol Chem. 2004;279 (30):31002-9. 22. Haas HS,Pfragner R,Siegl V,Ingolic E,Heintz E,Schraml E, Schauenstein K:The non-competitive metabotropic glutamate receptor-1 antagonist CPCCOEt inhibits the in vitro growth of human melanoma.Oncol Rep.2007;17(6):1399-404. 23. Huang XP, Hampson DR.Inhibition of microtubule formation by metabotropic glutamate receptors.J Neurochem.2000;74(1):104-13. 24. Moritz A,Scheschonka A,Beckhaus T,Karas M,Betz H.Metabo- tropic glutamate receptor 4 interacts with microtubule- associated protein 1B.Biochem Biophys Res Commun.2009;390(1): 82-6. 25. Serge A,Fourgeaud L,Hemar A,Choquet D.Active surface transport of metabotropic glutamate receptors through binding to microtubules and actin flow.J Cell Sci.2003;116(Pt24):5015-22. |