Abstract:

[Abstract] Objective To report a case of nevoid basal cell carcinoma syndrome and discuss its incidence, pathogenesis, clinical features and treatment. Methods Skin specimens were obtained from the patient and examined by histopathology , and relevant literatures were reviewed. Results A 48-year-old female presented with a 40-year history of with decades of crusted macules, varying in color from pink to brown and ranging in size from 0.5 to 3 mm in diameter, together with palmar keratotic plaques. Histopathology of skin specimens on the chest, abdomen and back revealed the presence of nests and lobules of basophile cells orderly settled, with a great amount of melanin pigmentation. The patient is mending after 3-month treatment with oral retinoid therapy . Conclusions The case is diagnosed as nevoid basal cell carcinoma syndrome by clinical features and histopathology findings, and was effectively treated by retinoic acid.

Key words: nevoid basal cell carcinoma syndrome, basal cell carcinoma