Chinese Journal of Dermatology ›› 2009, Vol. 42 ›› Issue (2): 143-143.

• Prologue • Previous Articles     Next Articles

Expression of endothelin-1, endothelin converting enzyme and tumor necrosis factor-α in seborrheic keratosis

WU Juan   

  • Received:2008-02-26 Revised:2008-03-25 Online:2009-02-15 Published:2009-02-15
  • Contact: WU Juan E-mail:wj_whu@126.com

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Abstract:

Objective: To investigate the expression of ET-1、ECE-1 and TNF-α in pathogenesis of seborrheic keratosis (SK) . Methods: The ET-1、ECE-1 and TNF-α expression in sit u in 30 cases of SK and 10 cases of normal skin tissue were examined by immunohisto-chemistry assay. Results : The expressive intensity of ET-1、ECE-1 and TNF-αin the SK group was significantly higher than that in the controls. Conclusions: These findings suggest that the increased secretion of ET-1 leading to enhanced pigmentation in SK results from the co-ordinated increased expression of TNF-α and ECE-1.