Abstract: Objective To investigate the role of the expression of latent transforming growth factor beta binding protein-1 （LTBP-1） and transforming growth factor beta receptor typeⅡ（TGF-beta RⅡ） in the pathogenesis of condyloma acuminatum （CA）. Methods Samples were resected from the lesions of 30 patients with CA and prepuces of 17 normal human controls. The mRNA and protein expressions of LTBP-1 and TGF-betaRⅡ were assessed by quantitative real-time PCR and a streptavidin-biotin-peroxidase staining technique, respectively. Results As shown by Real time PCR, the mRNA expression levels of LTBP-1 and TGF-betaRⅡ were significantly higher in CA tissues than those in the controls, with the average value of 2 （-Delta Delta Ct ） being 2.46 and 3.43, respectively. A lower intensity of stainning was observed for LTBP-1 and TGF-betaRⅡ in CA tissues compared with the normal controls（182.51 ± 9.89 vs 167.78 ± 12.56, 187.35 ± 11.23 vs 170.15 ± 13.21, t = 5.62, 3.70 respectively, both P < 0.01). Conclusion The decrease in the expression of both LTBP-1 and TGF-betaRⅡ may lead to the abnormality in the activation of TGF-beta and signal transduction pathways.

Key words: Condyloma acuminatum, Transforming growth factor beta, Latent TGFβbinding protein, TypeⅡreceptor,transforming growth factor beta