Abstract: 【Abstract】Objective: To investigate the clinical efficacy and adverse effect of orsalin ointment to treat chronic eczema and neurodermatitis. Methods: 152 patients with chronic eczema and neurodermatitis were randomly assigned to two groups: one was a treatment group including 76 patients being treated with orsalin ointment (45 cases with chronic eczema and 31 cases with neurodermatitis), another was a control group including 75 patients being treated with clobetasol propionate (43 cases with chronic eczema and 32 cases with neurodermatitis).The Therapeutic efficacy and adverse effect was evaluated after treating one week,two weeks and three weeks. Results :After one week’s treatment, the healing rate was 13.16 % in the treatment group and 6.67% in the control group, there was no significant difference between the two groups(P>0.05). After two and three weeks’ treatment, the healing rate was 53.95% and 63.16% in the treatment group respectively, while that of control group was 28.00% and 37.33 % respectively, there was a significant difference between the two groups(P<0.05).The clinical effective rate of treatment group was 43.42%, 84.21% and 92.11% respectively as compared with that of control group was 18.67%,60.00% and 69.33% respectively, there was a significant difference both in the two groups (both P<0.05) and no obvious side effect was found in the two groups. Conclusion: orsalin ointment is a more suitable dermatologic topical preparation in the treatment of chronic eczema and neurodermatitis.

Key words: Chronic eczema, Neurodermatitis, orsalin ointment, Compound Flumetasone ointment, Clobetasol propionate