Abstract: Objective To assess the efficacy and safety of 308 nm excimer laser plus topical pimecrolimus 1% cream for the treatment of vitiligo in childhood. Methods Forty-nine patients with bilateral symmetrical vitiligo lesions were enrolled, and randomly divided into two groups: group A, receiving 308 nm excimer laser therapy twice weekly as well as topical pimecrolimus cream twice daily; group B, singly receiving 308 nm excimer laser therapy twice weekly. All patients were treated for 15 weeks. Efficacy was evaluated after 15 and 30 times of laser therapy respectively. Results Except for one patient, all patients were able to be evaluated for efficacy. After 30 times of laser therapy, the response and excellent response rates were 89.6% and 77.1% respectively in group A, 75.0% and 52.1% respectively in group B; both rates were significantly higher in group A than in group B （both P < 0.05）. Also, a higher repigmentation rate was obtained in facial lesions in group A compared with group B. Conclusions The 308 nm excimer laser is safe, effective and well-tolerated for vitiligo in childhood, and the combination with topical pimecrolimus cream may improve its efficacy in facial vitiligo.