Abstract: 【Abstract】 Objective To evaluate the clinical efficacy of concentrated growth factor in improving skin flap ischemia-reperfusion injury. Methods Data were collected from 16 patients with ischemia-reperfusion injury in skin flaps after surgery at the Hangzhou Third People′s Hospital from January 2019 to August 2024. Ten males and 6 females were included. According to the sites of ischemic flaps, the 16 patients were divided into two groups: an experimental group （8 cases） receiving multi-point injections of concentrated growth factor at a dose of approximately 0.2 ml per point in the ischemic part of the flap at intervals of 0.5 cm; a control group （8 cases） receiving conventional dressing changes. The color, texture and ischemic area of the skin flaps were observed. The t test was used for comparisons between groups. Results In the experimental group, the preoperative ischemic area was 406.6 ± 245.2 mm2, which decreased to 66.6 ± 80.6 mm2 one week after treatment; the effective treatment area was 340.0 ± 263.9 mm2, resulting in a treatment response rate of 79.8% ± 26.4%. In the control group, the preoperative ischemic area was 440.8 ± 208.4 mm2, which decreased to 346.9 ± 189.8 mm2 one week after treatment; the effective treatment area was 93.9 ± 43.1 mm2, with a response rate of 26.4% ± 18.2%. The treatment response rate was significantly higher in the experimental group than in the control group （t = 4.71, P = 0.001）. Conclusion Concentrated growth factor can improve postoperative ischemia-reperfusion injury in skin flaps.

Key words: Surgical flaps, Reperfusion injury, Intercellular signaling peptides and proteins, Dermatologic surgical procedures, Concentrated growth factor