Abstract: Objective To investigate whether there is a possible pathogenic relationship between bullous pemphigoid （BP） and neurological disorders （ND）. Methods The reactivity of the sera was assessed by immunoblotting method in 12 patients with BP and ND, 15 with ND only, 42 with BP only and 30 normal controls. The antigens were prepared with the extracts from normal human skin and mouse brain tissue. Results Most sera from patients with BP and ND or BP only could recognize the antigens of 230 000, 180 000 and 165 000 （Mr） in human skin. The antigens in mouse brain were recognized by the sera from 10 （83%） patients with BP and ND, 5 （12%） with BP only, and 2 （13%） with ND only. No reactivity was observed between the normal control sera and the antigens from human skin or mouse brain. The sera of 3 BP patients accompanied with cerebral hemorrhage could recognize the BPAg1, an antigen of 230 000 （Mr）, in human skin and mouse brain at the same time. Conclusions These results suggest that both skin and brain can express BPAg1, which can be recognized by the sera of patients with BP and ND. The antibodies against brain tissue antigens in the sera of BP patients may play a role in the concurrence of BP and ND.