PI3K/Akt/mTOR信号通路在皮肤鳞状细胞癌中的研究进展

doi:10.35541/cjd.20200155

Chinese Journal of Dermatology ›› 2022, Vol. 55 ›› Issue (3): 264-267.doi: 10.35541/cjd.20200155

• Reviews • Previous Articles Next Articles

The research progress of PI3K/Akt/mT0R signaling pathway in cutaneous squamous cell carcinoma

Xu Congcong, Chen Hao

Department of Pathology, Hospital of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China

Received:2020-02-22 Revised:2020-07-23 Online:2022-03-15 Published:2022-03-03
Contact: Chen Hao E-mail:ch76ch@163.com
Supported by:
Six Talent Peaks Project in Jiangsu Province （WSN-030）; CAMS Innovation Fund for Medical Sciences （CIFMS-2017-I2M-1-017）

Abstract

Abstract: 【Abstract】 The pathogenesis of cutaneous squamous cell carcinoma （cSCC） is complicated, and treatment methods of advanced cSCC remain insufficient. This review summarizes the role of phosphatidylinositol 3-kinase （PI3K）/protein kinase B （Akt）/mammalian target of rapamycin （mTOR） signaling pathway in the pathogenesis of cSCC, as well as progress in the treatment of cSCC targeting this pathway, and provides new ideas for targeted therapy of cSCC.

Key words: Neoplasms, squamous cell, Signal transduction, Skin, PI3K/Akt/mTOR

Xu Congcong, Chen Hao. The research progress of PI3K/Akt/mT0R signaling pathway in cutaneous squamous cell carcinoma[J]. Chinese Journal of Dermatology, 2022, 55(3): 264-267.doi:10.35541/cjd.20200155

[1]	Sun Xiaojie, Liu Yi. Anti-androgen drugs in the treatment of skin diseases [J]. Chinese Journal of Dermatology, 2023, 56(9): 882-885.
[2]	Yue Chao, Duan Mengying, Wang Tao, Zhang Manyu, Dai Yeqin, Peng Jianzhong, Song Xiuzu. Application of the upper eyelid orbicularis oculi myocutaneous island flap in repairing secondary defects after resection of eyelid and periorbital skin tumors: a retrospective analysis of 28 cases [J]. Chinese Journal of Dermatology, 2023, 56(9): 862-865.
[3]	Chen Chunli, Yan Siyu, Wang Dan, Gao Lihua, Tan Lina, Tang Siyuan, Liu Wei, Zeng Jinrong, Lu Jianyun, . Efficacy of acidified aliphatic ester in the treatment of atopic dermatitis in mouse models and preliminary exploration of its mechanisms of action [J]. Chinese Journal of Dermatology, 2023, 56(9): 822-831.
[4]	Jing Ke, Wang Yuan, Li Suo, Feng Suying. Autoimmune subepidermal bullous diseases characterized by annular erythema and blisters: a retrospective analysis of 25 cases [J]. Chinese Journal of Dermatology, 2023, 56(9): 832-838.
[5]	Chen Yaolong, Liu Hui, Yao Zhirong, Gao Xinghua. Strategies and suggestions for improving the quality of guidelines and consensus in the field of dermatology [J]. Chinese Journal of Dermatology, 2023, 56(9): 805-808.
[6]	Jia Tao, Song Xiangjin, Geng Songmei. Autoinflammatory dermatosis [J]. Chinese Journal of Dermatology, 2023, 56(8): 794-799.
[7]	Wang Li, Ren Zengguo, Lou Guiyu, Zhang Yuwei, Yang Ke, Lei Xingxing, Zhang Bing, Liao Shixiu, Hao Bingtao. Genetic diagnosis in two families with dystrophic epidermolysis bullosa [J]. Chinese Journal of Dermatology, 2023, 56(8): 770-773.
[8]	Zhang Xiaodong, Wang Manya, Zhu Yingjie, Luo Tiande, Liu Xiaoming. Application of fluorescence staining in the detection of Demodex mites in the facial skin [J]. Chinese Journal of Dermatology, 2023, 56(8): 766-769.
[9]	Zhang Li, Shi Jian, Ge Xin, Liu Niannian, Chen Sai, Zhang Dongmei, Miao Xu. Effects of the interaction between Brahma-related gene 1 and activating transcription factor 2 on the proliferation, migration and invasion of cutaneous squamous cell carcinoma cells [J]. Chinese Journal of Dermatology, 2023, 56(8): 724-736.
[10]	China Dermatologist Association. Guidance on application of moisturizers and emollients: an expert consensus （2023） [J]. Chinese Journal of Dermatology, 2023, 56(8): 711-717.
[11]	Huang Xiaoyan, Xiao Yi, Jing Danrong, Chen Mingliang, Shen Minxue, . A survey on the prevalence and associated factors of arsenic poisoning-related skin lesions in an arsenic tailing area in Hunan Province, China [J]. Chinese Journal of Dermatology, 2023, 56(7): 636-641.
[12]	Li Yue, Wu Jinyan, Yuan Ruoyue, Yang Quyang, Zhao Xiansheng, Zhu Ningwen. Cell therapy for hereditary epidermolysis bullosa [J]. Chinese Journal of Dermatology, 2023, 56(7): 698-702.
[13]	Chen Qiquan, Kong Minmin, Yang Xianjie, Wang Huan, Li Jian, Zhang Mingwang, Song Zhiqiang. Clinical analysis of allergen reactivity and atopic disease history in 168 patients with chronic inducible urticaria [J]. Chinese Journal of Dermatology, 2023, 56(6): 496-503.
[14]	Wei Jin, Yan Huiwen, Zhao Tianwei, Ran Liwei, Lun Wenhui, Zhang Jianzhong. Eczematoid clear cell acanthoma of the nipple/areola: the first case reported in China and literature analysis [J]. Chinese Journal of Dermatology, 2023, 56(6): 545-548.
[15]	Ren Fenfen, Wang Peng, Zhang Jingzhan, Kang Xiaojing. Network pharmacology-based prediction of potential effective components of traditional Chinese medicine and their molecular mechanisms of action in the anti-angiogenic treatment of Kaposi′s sarcoma [J]. Chinese Journal of Dermatology, 2023, 56(5): 428-433.

The research progress of PI3K/Akt/mT0R signaling pathway in cutaneous squamous cell carcinoma

PDF

PDF (Mobile)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Metrics

Comments

Recommended 10