Abstract: Geng Qingwei, Wang Min, Song Xiuzu Department of Dermatology, Hangzhou Clinical College Affiliated to Anhui Medical University, Hangzhou 310009, China Corresponding author: Song Xiuzu, Email: songxiuzu@sina.com 【Abstract】 Objective To investigate clinical and histopathological features of cutaneous epithelioid hemangioma （EH）. Methods Clinical and histological data were collected from 22 patients with EH and analyzed. Results Of the 22 EH patients, 10 were male, and 12 were female. The age at onset ranged from 16 to 62 years, with an average age of 45.91 years. The duration of disease varied from 1 month to 20 years, with an average disease duration of 37 months. Skin lesions most frequently occurred on the scalp in 14 cases （63.6%）, followed by the ear in 6 cases （27.3%）, the forehead in 2 cases （9.1%）, and the thigh in 1 case （4.5%）. Lesions affected both the scalp and forehead in 1 case. Histopathological examination of the 22 cases revealed vascular proliferation. The blood vessels were lined with epithelioid endothelial cells, and a large number of lymphocytes and eosinophils infiltrated around the vessels. The dermis were involved in all cases, and subcutaneous tissues were involved in 8 cases （36.4%）. Immunohistochemical examination of 6 cases showed positive staining for CD31, CD34 and factor Ⅷ in blood vessel walls. Conclusion EH is an uncommon disease characterized by vascular proliferation and inflammatory infiltration, and clinical manifestations in combination with histopathological examination facilitate its diagnosis.

Key words: Angiolymphoid hyperplasia with eosinophilia, Epithelioid hemangioma, Kimura disease