Chinese Journal of Dermatology ›› 2017, Vol. 50 ›› Issue (10): 748-750.doi: 10.3760/cma.j.issn.0412-4030.2017.10.013

• Research Reports • Previous Articles     Next Articles

Relationship between human papillomavirus genotypes in and clinical characteristics of adult plantar warts

Dong Qiang, Yang Fan, Ren Yingyun, Xia Tianbao, Yin Mengmeng, Wang Zekun, Mi Xia,#br# Liu Junlian, Cao Xiaojia, Liu Jianjun, Ge Yun, Liang Long, Lyu Shichao#br#   

  1. Department of Dermatology, 306th Clinical College of People′ s Liberation Army, Anhui Medical University, Beijing 100101, China（Dong Q, Xia TB, Yin MM, Wang ZK, Mi X, Liu JL, Cao XJ, Liu JJ, Ge Y, Liang L , Lyu SC）; Department of Medical Cosmetology, The People′ s Hospital of Wu Qing, Tianjin 301700, China （Yang F）; Department of Dermatology, The Third People′s Hospital, Nanhai District, Foshan City, Foshan 528200, Guangdong, China（Ren YY）
  • Received:2016-12-01 Revised:2017-06-08 Online:2017-10-15 Published:2017-09-29
  • Supported by:
    Capital Clinical Characteristic Application Research（Z141107002514179）

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Abstract: Dong Qiang, Yang Fan, Ren Yingyun, Xia Tianbao, Yin Mengmeng, Wang Zekun, Mi Xia, Liu Junlian, Cao Xiaojia, Liu Jianjun, Ge Yun, Liang Long, Lyu Shichao Department of Dermatology, 306th Clinical College of People′s Liberation Army, Anhui Medical University, Beijing 100101, China（Dong Q, Xia TB, Yin MM, Wang ZK, Mi X, Liu JL, Cao XJ, Liu JJ, Ge Y, Liang L , Lyu SC）; Department of Medical Cosmetology, The People′s Hospital of Wu Qing, Tianjin 301700, China（Yang F）; Department of Dermatology, The Third People′s Hospital, Nanhai District, Foshan City, Foshan 528200, Guangdong, China（Ren YY） Corresponding author: Lyu Shichao, Email: lvshichao@sina.com 【Abstract】 Objective To investigate human papillomavirus （HPV） genotypes in adult patients with plantar warts, and to explore their relationship with clinical features of adult plantar warts. Methods PCR, gene sequencing and TA-cloning technique were performed to detect HPV types in 221 patients with plantar warts. Meanwhile, clinical data were recorded, including patients′ age, disease duration, symptoms and number of warts. Results Of 221 specimens, HPV DNA was detected in 215, with the HPV-positive rate being 97%. Single HPV infections were detected in 206 specimens （96%, 206/215）, among which, HPV types included HPV-27 （44.7%, 92/206）, -2 （12.1%, 25/206）, -57 （7.3%, 15/206）, -7 （Alpha genus; 0.5%, 1/206）, -65 （Gamma genus; 0.5%, 1/206）, -1 （33.5%, 69/206） and -63 （Mu genus; 1.5%, 3/206）. There were no significant differences in age, disease duration, number of warts, incidence of pain and gender among patients with HPV-27, -2 or -57 infections. Compared with patients with HPV-27 infection, patients with HPV-1 infection were more related to age ≤ 30 years, disease duration ≤ 1 year, number of warts ≤ 2 and high incidence of pain. Conclusion HPV-27, -2, -57 and -1 are the main types in adult patients with plantar warts, and HPV types are correlated with clinical features of adult plantar warts.

Key words: Papillomaviridae, Genotyping techniques, Warts, PCR, Clinical features, TA cloning