Abstract: Wang Lian, Li Mengmeng, Xu Fei, Yan Wei, Li Wei Department of Dermatology and Venereology, West China Hospital, Sichuan University, Chengdu 610041, China Corresponding author: Li Wei, Email: liwei@mcwcums.com 【Abstract】 Objective To summarize the clinical features, treatment and prognosis of bullous systemic lupus erythematosus （BSLE）. Methods Clinical data were collected from 6 cases of BSLE between May 2009 and September 2015, and were analyzed retrospectively. Results Among the 6 patients, 2 were male and 4 were female. The mean age of onset was 34 years. All the 6 patients presented with tense blisters and bullae arising on an erythematous base or normal skin, which were arranged in an annular pattern in 3 patients. The SLE Disease Activity Index （SLEDAI） score was > 4 in all the 6 patients. Histopathological examination showed subepidermal blisters or fissures in all the patients. Direct immunofluorescence （DIF） revealed continuous linear deposition of immunoglobulin G （IgG）, IgM and IgA in all the patients, linear deposition of C3 in 4 patients, and linear deposition of C1q in 2 patients at the basement membrane zone （BMZ）. All the 6 patients were treated with oral glucocorticoids and hydroxychloroquine, and 2 patients were additionally treated with cyclophosphamide. During the follow?up period, adverse reactions to different extents were observed in the 6 patients. Conclusions BSLE mainly occurs in young and middle?aged people. Histopathologically, subepidermal blisters or fissures can be observed with linear deposition of IgG, IgM, IgA, or C3 along the basement membrane zone on DIF.