Abstract:

Li Yan, Xu Wei, Li Linfeng Department of Dermatology and Venereology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China Corresponding authors: Xu Wei, Email: 2403649155@qq.com; Li Linfeng, Email: zoonli@sina.com 【Abstract】 Objective To evaluate the clinical efficacy and safety of topical glucocorticoids combined with a moisturizer containing antimicrobial peptides in the treatment of persistent localized eczema. Methods A total of 60 patients with localized eczema were divided into 2 groups. Group 1 topically applied Fuqing gel （an antimicrobial dressing） and hydrocortisone butyrate cream twice a day for 2 weeks, and group 2 topically applied the vehicle of Fuqing gel and hydrocortisone butyrate cream twice a day for 2 weeks. Recovered patients were followed up once every 4 weeks for 12 weeks. Bacterial culture was performed for 5 patients with suspected local Staphylococcus. aureus infection, including 3 patients in group 1 and 2 in group 2, before and after the 2-week treatment. Therapeutic effects were evaluated and compared between the two groups. Results Compared with group 2, group 1 showed a signifi-cantly higher response rate after 1-week treatment （χ2 = 5.455, P < 0.05）, but significantly lower eczema area and severity index （EASI） scores after 1- and 2-week treatment （both P < 0.05）. Before the treatment, S. aureus was detected in all the 5 patients. After 2-week treatment, S. aureus was undetected in all the 3 patients in group 1, but was still detected in the other 2 patients in group 2. The treatment was rated as ineffective in none of 7 recovered patients in group 1 during the 12-week follow up, but in 2 of 5 recovered patients in group 2 at week 10. Conclusion Fuqing gel combined with glucocorticoid ointment is safe and effective for the treatment of localized eczema, and can be applied in clinic.