Abstract:

Zhao Wei, Yu Qian, Ding Yangfeng, Xie Shaoqiong, Shi Yuling Shanghai Dermatology Hospital, Shanghai 200050, China （Zhao W, Ding YF, Xie SQ）; Department of Dermatology, Tenth People′s Hospital of Tongji University, Shanghai 200072, China （Zhao W, Yu Q, Shi YL） Corresponding author: Shi Yuling, Email: shiyuling1973 @tongji.edu.cn 【Abstract】 Objective To investigate the prevalence of psoriatic arthritis （PsA） in patients with psoriasis and its clinical features. Methods A cross-sectional study was conducted among patients diagnosed with psoriasis from January 2014 to January 2015. Through a questionnaire survey, the diagnosis of PsA was confirmed according to the Classification Criteria for Psoriatic Arthritis （CASPAR） in patients with suspected PsA. Clinical data were collected from patients with newly and previously diagnosed PsA. Statistical analysis was carried out by t test for two-group comparisons, one-way analysis of variance （ANOVA） for multi-group comparisons, and chi-square test for comparisons of rates. All the statistical tests were two-sided. Results Totally, 1 062 outpatients with psoriasis were enrolled into this study, and 125 were suspected to have PsA. According to the CASPAR, 70 （6.59%） patients were finally diagnosed with PsA, with the ratio of male to female being 2.1∶1, and 45 of them （64.29%） were newly diagnosed. Psoriasis vulgaris lesions were observed in 50 （71.43%） patients with PsA, and were the most common type of skin lesions in patients with PsA. There were 5 clinical types of PsA in these patients, including asymmetrical oligoarthritis （23 cases, 32.86%）, symmetric polyarthritis （19 cases, 27.14%）, distal interphalangeal predominant arthritis （10 cases, 14.29%）, vertebral or sacroiliac arthropathy （7 cases, 10.00%）, and arthritis mutilans （11 cases, 15.71%）, with some overlap among these clinical types. As relatively distinctive manifestations of PsA, dactylitis and enthesitis were observed in 14 （20.00%） and 8 cases （11.43%） respectively. In addition, 43 （61.43%） cases had nail involvements. Conclusion To master clinical features of PsA and to diagnose it early are of great significance for long-term prognosis of PsA patients.