Abstract: Lu Xueyan, Huang Ershun, Tan Yanhong, Li Linfeng. Department of Dermatology, Peking University Third Hospital, Beijing 100191, China Corresponding author: Li Linfeng, Email: zoonli@tom.com 【Abstract】 Objective To evaluate the efficacy and safety of maintenance treatment with Qingpeng ointment in the prevention of recurrence of localized eczema. Methods Totally, 197 patients with localized eczema were topically treated with halometasone cream for 2 － 4 weeks. The patients who achieved clinical cure were then randomly classified into two groups to receive maintenance treatment with Qingpeng ointment （Qingpeng group, n = 69） or vitamin E-containing cream （emollient group, n = 68）. Patients were followed up for 8 weeks for the detection of recurrence after the discontinuation of maintenance treatment. Results During the follow up, the recurrence rate in the Qingpeng group was significantly lower than that in the emollient group（19.70% vs. 37.31%, χ2 = 5.06, P <0.05）. Significant differences were also observed in the duration of remission between the Qingpeng group and emollient group （（43.92 ± 15.70） vs. （32.60 ± 14.40） days, t = 2.23, P < 0.05）. The incidence rate of adverse reactions was 1.45% in the Qingpeng group during the maintenance treatment, and no adverse reactions were observed in the emollient group. Conclusion The maintenance treatment with Qingpeng ointment can delay the recurrence of localized eczema to some extent with a favorable safety.

Key words: Eczema, Maintenance treatment, Qingpeng ointment