Chinese Journal of Dermatology

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Expression of CD147,cyclophilin A and cyclophilin B in psoriatic lesions

CHEN Xiang, LI Juan, SU Juan, WU Yi-xi, CHANG Jing, PENG Sheng, KUANG Ye-hong   

  1. Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China
  • Received:2006-11-17 Online:2007-10-15 Published:2007-10-15

Abstract: Objective To study the expression and pathologic significance of CD147,cyclophilin A (CyPA)and cyclophilin B(CyPB)in psoriatic lesions.Methods Immunohistochemical method was applied to detect the expression of CD147,CyPA and CyPB in skin specimens of 15 patients with psoriasis pustulosa(PP),20 patients with progressive psoriasis vulgaris(PPV),and 20 patients with inactive psori-asis vulgaris(IPV).Immunoreactivity intensity distribution index(IRIDI)was calculated to assess the expression intensity of CD147,CyPA and CyPB.Results CD147,CyPA and CyPB were detected in all specimens.The IRIDI scores of CD147 and CyPA were significantly higher in keratinocytes of psoriatic lesions than in those of the control specimens(all P<0.05),in keratinocytes,T cells and neutrophils of PP lesions than in those of PPV lesions(all P<0.05),in T lymphocytes and neutrophils of PPV lesions than in those of IPV lesions(all P<0.05).There was no significant difference in the keratinocytes of PPV and IPV lesions(P>0.05).The IRIDI score of CyPB in T lymphocytes of PP lesions was significantly elevated than that in PPV lesions,which was in turn higher than that in IPV lesions(all P<0.05).However,no significant difference was found in the IRIDI score of CyPB among the keratinocytes of all groups,or among the neutrophils of the three psoriatic groups(all P>0.05).Conclusion CD147,CyPA and CyPB may play a role in the occurrence and development of psoriasis.

Key words: Psoriasis, Antigens, CD147, Cyclophilins, T-lymphocytes, Neutrophils