Abstract: Ma Qianqian, Wu Qian, Zhang Liming, Xiao Ting, Li Jiuhong, Geng Long, He Chundi *. *Department of Dermatology, No.1 Hospital of China Medical University, Shenyang 110001, China Corresponding author: He Chundi, Email: chundihe@hotmail.com 【Abstract】 Objective To analyze the clinical features of patients with dermatomyositis （DM）/polymyositis（PM） associated with interstitial lung disease（ILD）. Methods Clinical data were collected on 432 inpatients with DM/PM from September 2004 to June 2012 in the No. 1 Hospital of China Medical University. Of these patients, 85 with and 79 without complicated ILD were eligible for this study. All statistical analyses were carried out using SPSS 17.0 software. Chi-square test was performed for count data analysis, and t test for measurement data analysis. Results The incidence rate of fever was significantly higher （55.29% （47/85） vs. 22.78% （18/79）, P < 0.05）, but that of dysphagia was significantly lower （10.59% （9/85） vs. 24.05% （19/79）, P < 0.05）, in patients with complicated ILD than in those without. Moreover, the patients with complicated ILD showed significantly decreased serum levels of creatine kinase （CK） and l-lactate dehydrogenase （LDH） but increased levels of IgA, IgM, IgG and gamma globulin compared with those without complicated ILD （all P < 0.05）. Conclusions Compared with DM/PM patients without complicated ILD, those with complicated ILD are more likely to have fever with slightly elevated levels of CK, LDH and evidently elevated levels of IgA, IgM, IgG and gamma globulin in serum. Male patients with DM/PM seem to be more prone to ILD than female patients.

Key words: Dermatomyositis, Polymyositis, Lung diseases, interstitial, Retrospective studies