Abstract: Li Lina*, Zhang Shoumin, Ran Yuping, Kang Daoxian, Li Min, Chen Jing, Li Zhenlu, Wang Yuping, Li Jianguo, Gao Li, Wang Guofang. *Department of Dermatology and Venereology, Henan Provincial People′s Hospital, Zhengzhou 450003, China Corresponding authors: Li Zhenlu, Email: lizhenlu@sohu.com; Ran Yuping, Email: ranyuping@vip.sina.com 【Abstract】 A 50-year-old female farmer presented with nodules, plaques and ulcers on as well as erythematous swelling of the right upper limb for six years, plaques on the right buttock for two years and on the right cheek for one year. She had been treated with terbinafine and itraconazole, but no obvious improvement was achieved. Broad, septated and right-angled branching hyphae were found by both routine pathological examination and periodic acid-Schiff （PAS） staining of the lesional tissue from the right upper limb and buttock. The fungus was identified as Mucor irregularis by culture and molecular biological approaches, and the patient was diagnosed with primary cutaneous mucormycosis and given intravenous amphotericin B with the total dose being 1 060 mg. Subsequently, the plaques on and swelling of the right cheek and buttock gradually regressed, and the plaques on, swelling and necrosis of the right dorsal hand subsided with shedding of black crusts and formation of scar. The repeated fungal culture of lesional tissue on the right limb was negative. The patient was followed for one year and no recurrence was observed.

Key words: Mucor irregularis, Rhizomucor variabilis, Amphotericin B, Primary cutaneous mucormycosis