Abstract: PENG Yang*, WANG Ming-yue, HAN Ying, ZHU Xue-jun, CHEN Xi-xue. *Department of Dermatology, Peking University First Hospital, Beijing 100034, China Corresponding author: CHEN Xi-xue, Email: xixue_chen@163.com 【Abstract】 Objective To analyze the clinical features and treatment of 68 cases of mucous membrane pemphigoid （MMP）. Methods Clinical data were collected from 68 patients with MMP at the Department of Dermatology, Peking University First Hospital, between August 1987 and October 2012. Skin manifestations, histopathological and immunological findings were studied, with an emphasis on treatment regimens. Results The two most frequently involved sites were oral （67/68, 98.5%） and conjunctival （23/68, 33.8%） mucosa in patients with MMP. Immunological examinations included direct immunofluorescence test, indirect immunofluorescence test and enzyme-linked immunosorbent assay, with a positivity rate of 50% （8/16）, 20.5% （8/39） and 53.7% （22/41） respectively. According to lesion distribution and disease severity, patients were given local therapy （n = 5） or low to moderate dose of glucocorticoids （n = 55, 0.4 － 0.5 mg/kg or 30 mg per day）. The condition was controlled until the dose of glucocorticoids reached 50 mg/d in three patients with cutaneous, oral, ocular, and other mucosal involvement. The time to onset of action of glucocorticoids at the controlling dose was （11.80 ± 5.88） days, and the duration of administration of glucocorticoids at this dose varied from 0.23 to 12 months（average, 3.06 ± 2.84 months）. Fifteen patients were almost cured, and four patients completely cured. Of the 15 patients almost cured, the time required for a 50% reduction in the dose of glucocorticoids was（13.29 ± 5.76） months，and that required for the control of MMP was （17.33 ± 7.71） months. The dose of glucocorticoids was decreased to 76.5% of the controling dose at 6 months after the control of MMP, and 58.1% of that at 12 months. Oral candidiasis occurred in three patients during the treatment. Conclusions The diagnosis of MMP is mainly based on typical clinical and histopathological findings, and current immunological examinations are insufficiently sensitive. Usually, low to moderate dose of systemic corticosteroids combined with topical therapy can lead to satisfactory treatment outcomes. 【Key words】 Pemphigoid, benign mucous membrane; Retrospective studies; Drug therapy