Abstract: LI Yang, ZHU Yi-ping, XU Ai-e. Department of Dermatology, Third People′s Hospital of Hangzhou, Hangzhou 310009, China Corresponding author: XU Ai-e, Email: xuaiehz@msn.com 【Abstract】 Objective To characterize the progression of segmental vitiligo. Methods Clinical data were collected using questionnaires from 387 patients with segmental vitiligo at the Department of Dermatology, Third People′s Hospital of Hangzhou, between October 2011 and October 2012. The progression of segmental vitiligo was analyzed. Results Among the 387 patients, 329 initially sufferred from focal vitiligo that evolved into segmental vitiligo later, 58 began with segmental vitiligo. Vitiligo progressed most rapidly in the initial three months, and tended to be stable after three years in 220 （66.9%） of the 329 patients experiencing the evolution from focal to segmental vitiligo. By contrast, vitiligo developed most rapidly in the first month, and tended to be quiescent after one year in 40 （69.0%） of the 58 patients presenting with segmental vitiligo only. The condition still remained active in 27.6% （107/387） of these patients after several years of progression. Totally, 333（86.0%） patients showed the involvement of single ganglion at the onset of vitiligo, including 173 （52.0%） patients with the involvement of trigeminal ganglion. Autologous melanocyte transplantation was conducted for 62 patients whose condition had been quiescent for more than one year, and 56 （90.3%） patients achieved more than 80% repigmentation. Conclusions Segmental vitiligo, which tends to remain quiescent after three-year progression, seems to have a more rapid onset than focal vitiligo. Autologous melanocyte transplantation appears to be an effective treatment for segmental vitiligo in stable stage.