Abstract: WU Ping，WU Jin-qiong，WANG Li *，WU Di，CHEN Hua，LIU Yue-hua，FANG Kai, HE Chun-xia, HOU Yong, ZENG Xiao-feng， ZHANG Feng-chun. *Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College; Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing 100730, China Corresponding author: WANG Li, Email: wangli2221@sina.com 【Abstract】 Objective To assess the clinical characteristics of patients with scleredema. Methods This retrospective study included eight patients with scleredema hospitalized in the Peking Union Medical College Hospital（PUMCH） from 1998 to 2012. Data were collected from medical records. Clinical manifestations, pathological findings and therapeutic outcomes were analyzed. Results There were four male patients and four female patients with an average age of 44 years. Sclerotic induration of the skin on the neck, shoulders and back were observed in 6 （75%） patients, and multi-systemic involvement in 6 patients. Three of five patients with type 2 diabetes millitus（DM） suffered from diabetes-associated complications. Lambda type M-protein was observed in one patient, and Kappa type M-protein in one patient. Two patients also suffered from fever, and one from Sj?觟gren′s syndrome. Pathological examination of biopsy specimens from four patients revealed thickening of the whole dermis as well as marked hyperpasia of collagen. Alcian blue staining was positive in the space between collagen fibers. The condition was improved in three patients treated with glucocorticoid and immunosuppressants as well as in one patient receiving benzylpenicillin treatment, but poorly responded to ultraviolet therapy in one patient. Conclusions It is recommended to monitor blood glucose and serum immunoglobulins as well as to screen for the involvement of multiple systems and occurrence of multiple myeloma, lymphoma and other malignancies among patients with scleredema.