Abstract: XU Liang-heng*, LI Na, CHENG Bo, LI Hui, LIN Xin-yu, FAN Wen-ge, HUANG Yi-jin, CAO Ping, SUN Dong-jie, LIU Hai-yang, CHEN Ying, ZHAO Heng-guang, LIN Zhao-chun, TAO Xiao-yu, ZHANG Qi-guo, WU Yi-fei, HAO Jian-hua, HE Li, YIN Rui. *Yunnan Provincial Institute for Dermatology and Venereology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, China Corresponding authors: HE Li, Email: drheli2662@126.com；YIN Rui, Email：swyinrui@163.com 【Abstract】 Objective To evaluate the safety of Qingdou Xiufu Jinghua Ye, a skin care product containing the extract of Chinese manyleaf paris rhizome, purslane and sodium hyaluronate, in the improvement of acne vulgaris. Methods A multicenter, randomized, open-label, controlled study was conducted. Totally, 160 patients with acne vulgaris were equally classified into two groups to topically apply the modified Qingdou Xiufu Jinghua Ye containing the extract of Chinese manyleaf paris rhizome, purslane and sodium hyaluronate （experiment group） or the original Qingdou Xiufu Jinghua Ye containing papain, vitamin B3, extract of purslane, and salicylic acid derivate （control group）, twice a day after face washing with a commercial foaming face wash. The number of acne lesions was calculated at the baseline, on day 7, 14 and 28 after the start of intervention. Results Finally, 11 patients were lost to follow-up, and 149 patients completed the trial, including 73 patients in the experiment group and 76 patients in the control group. The number of inflammatory lesions and total lesions significantly decreased in both groups on day 14 and 28 compared with that before intervention （all P < 0.05）. No statistical difference was observed in the response rate between the two groups at any of the three time points after treatment （all P > 0.05）. Conclusion The topical application of modified Qingdou Xiufu Jinghua Ye containing the extract of Chinese manyleaf paris rhizome, purslane and sodium hyaluronate is beneficial to the improvement of acne vulgaris.