Abstract: Objective To explore the general rule of the development of severe drug eruptions. Methods Clinical data were retrospectively collected from 191 cases of severe drug eruptions,and classified according to time,types and causative drugs.Results The mean onset age of exfoliative dermatitis was older than that of toxic epidermal necrolysis and Steven-Johnson syndrome.Pneumonitis,septicaemia,alimentary tract hemorrhage and electrolyte disturbances were common complications.The mean age of patients with drug eruptions caused by antibiotics was older than that by antiepileptics.The latent period of eruptions caused by antiepileptics was longer than that by the other drugs.Conclusions The predominant causative drugs of severe drug eruptions are antipyretic analgesics,sulfonamides and antibiotics.Characteristic manifestations are observed for servere drug eruptions at different time,of different types and by different causative drugs.

Key words: Drug eruptions, Clinical analysis