Abstract: Objective To investigate the expression of and association between phosphorylated signal transducer and activator of transcription-3(p-Stat 3)and Cyclin D1 protein in psoriasis vulgaris. Methods Biopsy samples from 22 patients with psoriasis vulgaris were obtained,and subjected to immunohistochemical staining for p-Stat 3 and Cyclin D1 protein.Results Of the 22 specimens,19 and 20 were positive for p-Stat 3 and Cyclin D1 staining respectively.Both p-Stat 3 and Cyclin D1 were observed in the nuclei of spinous layer of epidermis,and p-Stat 3 was also expressed in some vascular endothelial cells. Moreover,there was a significant association between p-Star 3 and Cyclin D1 expression.Conclusion The Stat 3 signaling pathway may participate in the pathogenesis of psoriasis vulgaris.

Key words: Psoriasis, Cyclin D1, Stat 3